| 2.A.1 The Major Facilitator Superfamily (MFS)
The MFS is a very old, large and diverse superfamily that includes over a thousand sequenced members. They catalyze uniport, solute:cation (H+ or Na+) symport and/or solute:H+ or solute:solute antiport. Most are of 400-600 amino acyl residues in length and possess either 12, 14 or 24 putative transmembrane α-helical spanners. The 24 TMS MFS permease, NarK, of Paracoccus pantotrophus has two 12 TMS domains, NarK1 and NarK2, both of which are required for normal nitrate uptake. NarK1 catalyzes NO3-:H+ symport, dependent on the pmf, while NarK2 catalyzes NO3-:NO2- antiport, independent of the pmf (Wood et al., 2002). Thus, the protein is a fusion protein of two homologous but distinct MFS permeases.
MFS permeases exhibit specificity for sugars, polyols, drugs, neurotransmitters, Krebs cycle metabolites, phosphorylated glycolytic intermediates, amino acids, peptides, osmolites, siderophores (efflux), iron-siderophores (uptake), nucleosides, organic anions, inorganic anions, etc. They are found ubiquitously in all three kingdoms of living organisms. One member of the DHA2 family with 14 spanners, the TetL Me2+ · tetracycline:H+ antiporter of B. subtilis (TC #2.A.1.3.16), which also exhibits monovalent ion antiport activity, can be converted to a monovalent cation (Na+, K+, H+) antiporter with no tetracycline transport activity by deletion of TMSs 7 and 8, the two central and extra TMSs (Jin et al., 2001).
A 6.5 Å resolution structure for the MFS permease, OxlT (TC #2.A.1.11.1) has been obtained (Heymann et al., 2001; Hirai et al., 2002) which shows the positions of the transmembrane α-helices but does not allow assignment of the TMS # to these helices. Molecular modeling (Hirai et al., 2003) led to the suggestion that the 12 TMS protein arose from a 3 TMS element by two successive duplication events. The same suggestion resulted from sequence comparisons showing that the primordial 3 TMS element may have arisen from a VIC family (TC #1.A.1) 2 TMS channel-forming unit (Hvorup and Saier, 2003). TMSs 3, 6, 9 and 12 are hydrophobic while TMSs 1, 2, 4, 5, 7, 8, 10 and 11 line the channel. The protein may exhibit 4 fold symmetry.
The high-resolution 3-dimensional structures (3.3 and 3.5 Å resolution) of the glycerol-3-P:P antiporter (GlpT; TC #2.A.1.4.3) and the lactose:H+ symporter (LacY; TC #2.A.1.5.1), respectively (Huang et al., 2003 and Abramson et al., 2003, respectively; see also Locher et al., 2003) have been determined. These structures reveal the 2-fold symmetry expected, based on sequence similarity of the two halves. However, the 4-fold symmetry seen in the OxlT structure was not observed. The substrate pathway is predicted to exist between the two halves of the permeases using an alternating access mechanism with a single substrate binding site (Huang et al., 2003). This mechanism is termed a 'rocker switch' type of movement.
The generalized transport reactions catalyzed by MFS porters are:
(1) Uniport: S (out)  S (in).
(2) Symport: S (out) + [H+ or Na+] (out) S (in) + [H+ or Na+] (in).
(3) Antiport: S1 (out) + S2 (in) S1 (in) + S2 (out) (S1 may be H+ or a solute).
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This family belongs to the MFS Superfamily.
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| Macromolecular structures of proteins in this family: 2.A.1.4.3 - 1PW4
2.A.1.5.1 - 1PV6
2.A.1.5.1 - 1PV7
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Sato, M. and M. Mueckler. (1999). A conserved amino acid motif (R-X-G-R-R) in the Glut1 glucose transporter is an important determinant of membrane topology. J. Biol. Chem. 274: 24721-24725.
|
Schubbe, S., M. Kube, A. Scheffel, C. Wawer, U. Heyen, A. Meyerdierks, M.H. Madkour, F. Mayer, R. Reinhardt, and D. Schüler. (2003). Characterization of a spontaneous nonmagnetic mutant of Magnetospirillum gryphiswaldense reveals a large deletion comprising a putative magnetosome island. J. Bacteriol. 185: 5779–5790.
|
Schuldiner, S., A. Shirvan, and M. Linial. (1995). Vesicular neurotransmitter transporters: from bacteria to humans. Physiol. Rev. 75: 369-392.
|
Schwöppe, C., H.H. Winkler, and H.E. Neuhaus. (2002). Properties of the glucose-6-phosphate transporter from Chlamydia pneumoniae (HPTcp) and the glucose-6-phosphate sensor from Escherichia coli (UhpC). J. Bacteriol. 184: 2108-2115.
|
Shinnick, S.G., S.A. Perez, and M.F. Varela. (2003). Altered substrate selection of the melibiose transporter (MelY) of Enterobacter cloacae involving point mutations in Leu-88, Leu-91, and Ala-182 that confer enhanced maltose transport. J. Bacteriol. 185: 3672-3677.
|
Stolz, J., U. Hoja, S, Meier, N. Sauer, and E. Schweizer. (2000). Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant. J. Biol. Chem. 274: 18741-18746.
|
Tailor, C.S., B.J. Willett, and D. Kabat. (1999). A putatve cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. Virology 73: 6500-6505.
|
Tamai, I., R. Ohashi, J. Nezu, H. Yabuuchi, A. Oku, M. Shimane, Y. Sai, and A. Tsuji. (1998). Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem. 273: 20378-20382.
|
Tanabe, T., T. Funahashi, H. Nakao, S.-I. Miyoshi, S. Shinoda, and S. Yamamoto. (2003). Identification and characterization of genes required for biosynthesis and transport of the siderophore vibrioferrin in Vibrio parahaemolyticus. J. Bacteriol. 185: 6938-6949.
|
Tomitori, H., K. Kashiwagi, K. Sakata, Y. Kakinuma, and K. Igarashi. (1999). Identification of a gene for a polyamine transport protein in yeast. J. Biol. Chem. 274: 3265-3267.
|
Turner, M.S. and J.D. Helmann. (2000). Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the sigmaX and sigmaW factors in Bacillus subtilis. J. Bacteriol. 182: 5202-5210.
|
Uldry, M., M. Ibberson, J.D. Horisberger, J.Y. Chatton, B.M. Riederer, and B. Thorens. (2001). Identification of a mammalian H+-myo-inositol symporter expressed predominantly in the brain. EMBO J. 20: 4467-4477.
|
Uldry, M., M. Ibberson, M. Hosokawa, and B. Thorens. (2002). GLUT2 is a high affinity glucosamine transporter. FEBS Lett. 524: 199-203.
|
Verheijen, F.W., E. Verbeek, N. Aula, C.E. Beerens, A.C. Havelaar, M. Joosse, L. Peltonen, R. Aula, H. Galjaard, P.J. van der Spek, and G.M. Mancini. (1999). A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases. Nature Genet. 23: 462-465.
|
Wang, W., A.A. Guffanti, Y. Wei, M. Ito, and T.A. Krulwich. (2000). Two types of Bacillus subtilis tetA(L) deletion strains reveal the physiological importance of TetA(L) in K+ acquisition as well as in Na+, alkali, and tetracycline resistance. J. Bacteriol. 182: 2088-2095.
|
Wieczorke, R., S. Krampe, T. Weierstall, K. Freidel, C.P. Hollenberg, and E. Boles. (1999). Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. FEBS Lett. 464: 123-128.
|
Williams, P.A. and L.E. Shaw. (1997). mucK, a gene in Acinetobacter calcoaceticus ADP1 (BD413), encodes the ability to grow on exogenous cis,cis-muconate as the sole carbon source. J. Bacteriol. 179: 5935-5942.
|
Wilson, M.C., V.N. Jackson, C. Heddle, N.T. Price, H. Pilegaard, C. Juel, A. Bonen, I. Montgomery, O.F. Hutter, and A.P. Halestrap. (1998). Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. J. Biol. Chem. 273: 15920-15926.
|
Wood, N.J., T. Alizadeh, D.J. Richardson, S.J. Ferguson, and J.W.B. Moir. (2002). Two domains of a dual-function NarK protein are required for nitrate uptake, the first step of denitrification in Paracoccus pantotrophus. Mol. Microbiol. 44: 157-170.
|
Wu, X., R. Kekuda, W. Huang, Y.-J. Fei, F.H. Leibach, J. Chen, S.J. Conway, and V. Ganapathy. (1998). Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J. Biol. Chem. 273: 32776-32786.
|
Ye, L., Z. Jia, T. Jung, and P.C. Maloney. (2001). Toplogy of OxlT, the oxalate transporter of Oxalobacter formigenes, determined by site-directed fluorescence labeling. J. Bacteriol. 183: 2490-2496.
|
Yoshida, K.-I., Y. Yamamoto, K. Omae, M. Yamamoto, and Y. Fujita. (2002). Identification of two myo-inositol transporter genes of Bacillus subtilis. J. Bacteriol. 184: 983-991.
|
Young, C.S. and J.T. Beatty. (1998). A topological model of the Rhodobacter capsulatus light-harvesting I complex assembly protein LlaA (previously known as ORF1696). J. Bacteriol. 180: 4742-4745.
|
Zhang, C.C., M.C. Durand, R. Jeanjean, and F. Joset. (1989). Molecular and genetical analysis of the fructose-glucose transport system in the cyanobacterium Synechocystis PCC6803. Mol. Microbiol. 3: 1221-1229.
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Zhou, J., E. Fernández, A. Galván, and A.J. Miller. (2000). A high affinity nitrate/nitrite transport system from Chlamydomonas requires two gene products. FEBS Lett. 466: 225-227.
|
| Examples: |
| TC# | Name | Organismal Type | Example |
| 2.A.1.1 The Sugar Porter (SP) Family |
|
| 2.A.1.1.1 | Galactose:H+ symporter | Bacteria | GalP of E. coli |
| |
| 2.A.1.1.2 | Arabinose (xylose; galactose):H+ symporter | Bacteria | AraE of E. coli |
| |
| 2.A.1.1.3 | Xylose:H+ symporter | Bacteria | XylE of E. coli |
| |
| 2.A.1.1.4 | Glucose uniporter | Bacteria | Glf of Zymomonas mobilis |
| |
| 2.A.1.1.5 | Hexose uniporter | Yeast | HxtO of Saccharomyces cerevisiae |
| |
| 2.A.1.1.6 | Galactose, glucose uniporter (also transports xylose) | Yeast | Gal2 of Saccharomyces cerevisiae |
| |
| 2.A.1.1.7 | Quinate:H+ symporter | Fungi | Qay of Neurospora crassa |
| |
| 2.A.1.1.8 | Myoinositol:H+ symporter | Yeast | ITR1 of Saccharomyces cerevisiae |
| |
| 2.A.1.1.9 | Lactose, galactose:H+ symporter | Yeast | LacP of Kluyveromyces lactis |
| |
| 2.A.1.1.10 | Maltose:H+ symporter | Yeast | MAL6 of Saccharomyces cerevisiae |
| |
| 2.A.1.1.11 | General α-glucoside H+ symporter
(Trehalose, maltose turanose, isomaltose, α-methyl-glucoside, maltotriose, palatinose, trehalose and melezitose): H+ symporter, Gtr3 | Yeast | AGT1 of Saccharomyces cerevisiae |
| |
| 2.A.1.1.12 | Glucose uniporter (also transports dehydro-
ascorbate; Maulén et al., 2003) | Animals | Gtr3 (Glut3) of Rattus norvegicus (rat) |
| |
| 2.A.1.1.13 | Fructose uniporter | Animals | Ftr of Homo sapiens |
| |
| 2.A.1.1.14 | Hexose:H+ symporter | Plants | Hup1 of Chlorella kessleri |
| |
| 2.A.1.1.15 | Putative sugar transporter | Archaea | Porter of Sulfolobus sulfataricus |
| |
| 2.A.1.1.16 | Low-affinity hexose (glucose, fructose, mannose, 2-deoxyglucose) uniporter | Protozoa | Gtr2 (D2) of Leishmania donovani |
| |
| 2.A.1.1.17 | Glucose transporter | Protozoa | Th2A of Trypanosoma brucei |
| |
| 2.A.1.1.18 | Glucose (low) sensor | Yeast | Snf3p of Saccharomyces cerevisiae |
| |
| 2.A.1.1.19 | Glucose (high) sensor | Yeast | Rgt2p of Saccharomyces cerevisiae |
| |
| 2.A.1.1.20 | Myoinositol:H+ symporter, MIT | Protozoa | MIT of Leishmania donovani; most similar to ITRI of Saccharomyces cerevisiae |
| |
| 2.A.1.1.21 | Hexose:H+ symporter, Ght2 (Glucose > Fructose) | Yeast | Ght2 of Schizosaccharomyces pombe |
| |
| 2.A.1.1.22 | Hexose:H+ symporter, Ght6 (Fructose > Glucose) | Yeast | Ght6 of Schizosaccharomyces pombe |
| |
| 2.A.1.1.23 | Gluconate:H+ symporter, Ght3 | Yeast | Ght3 of Schizosaccharomyces pombe |
| |
| 2.A.1.1.24 | Hexose (Glucose and Fructose) transporter, PfHT1 | Protozoa | PfHT1 of Plasmodium falciparum |
| |
| 2.A.1.1.25 | Myoinositol:H+ symporter, HMIT (also transport other inositols including scillo-, muco- and chiro-, but not allo-inositol) | Animals | HMIT of Homo sapiens |
| |
| 2.A.1.1.26 | Major myoinositol:H+ symporter, IolT | Bacteria | IolT (YdjK) of Bacillus subtilis |
| |
| 2.A.1.1.27 | Minor myoinositol:H+ symporter, IolF | Bacteria | IolF of Bacillus subtilis |
| |
| 2.A.1.1.28 | The erythrocyte/brain hexose facilitator,
Gtr1 or Glut1. Also transports dehydro-
ascorbate and water via distinct channels. (Receptor for human T-cell leukemia virus (HTLV) (Manel et al., 2003)) | Animals | Gtr1 of Homo sapiens |
| |
| 2.A.1.1.29 | Glucosamine/glucose uniporter, Glut-2 (may also transport dehydroascorbate; Maulén et
al., 2003) | Animals | Glut2 of Homo sapiens |
| |
| 2.A.1.1.30 | Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1) (also transports arsenic trioxide [As(OH)3] as do Hxtl, 3, 5, 7 and 9) (Liu et al., 2004) | Yeast | Hxt4 of Saccharomyces cerevisiae |
| |
| 2.A.1.1.31 | High affinity, glucose-repressible, glucose (hexose) uniporter (Hxt6) | Yeast | Hxt6 of Saccharomyces cerevisiae |
| |
| 2.A.1.1.32 | Glucose/fructose:H+ symporter, GlcP (Zhang et al., 1989) | Bacteria | GlcP of Synechocystis sp. (P15729) |
| |
| 2.A.1.1.33 | Fructose:H+ symporter of Kluyveromyces lactis, Frt1 (Diezemann and Boles, 2003) | | |
| |
| 2.A.1.2 The Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family |
|
| 2.A.1.2.1 | Amiloride:H+ antiporter | Yeast | Car1 of Schizosaccharomyces pombe |
| |
| 2.A.1.2.2 | Cycloheximide:H+ antiporter | Yeast | CyhR of Candida maltosa |
| |
| 2.A.1.2.3 | Chloramphenicol:H+ antiporter; multidrug exporter; isopropyl β-thiogalactoside exporter | Bacteria | CmlA of Pseudomonas aeruginosa |
| |
| 2.A.1.2.4 | Tetracycline:H+ antiporter | Bacteria | TetA of E. coli |
| |
| 2.A.1.2.5 | Multidrug (14- and 15-membered macrolides, lincosamides, streptogramins, tetracyclines, daunomycin, ethidium bromide, etc.):H+ antiporter | Gram-positive bacteria | LmrP of Lactococcus lactis |
| |
| 2.A.1.2.6 | (Benomyl, cycloheximide, methotrexate, fluconazole, etc.):H+ antiporter | Yeast | CaMDR1 of Candida albicans |
| |
| 2.A.1.2.7 | (Bicyclomycin, sulfathiazole, tetracycline, fosfomycin, acriflavin, etc.):H+ antiporter | Gram-negative bacteria | Bcr of E. coli |
| |
| 2.A.1.2.8 | (Spermidine; fluoroquinolones, acriflavin, chloramphenicol, ethidium bromide, etc.):H+ antiporter | Gram-positive bacteria | Blt of Bacillus subtilis |
| |
| 2.A.1.2.9 | (Hydrophobic uncoupler e.g., CCCP, benzalkonium, SDS):H+ antiporter | Gram-negative bacteria | EmrD of E. coli |
| |
| 2.A.1.2.10 | Quinolone (and other drug):H+ antiporter | Bacteria | NorA of Staphylococcus aureus |
| |
| 2.A.1.2.11 | Monoamine transporter; drug (doxorubicin, ethidium bromide-6-G):H+ antiporter | Animals | VMAT1 of Rattus norvegicus |
| |
| 2.A.1.2.12 | Chromaffin granule monoamine (and drug) transporter, VAT1 | Animals | VAT1 of Homo sapiens |
| |
| 2.A.1.2.13 | Acetylcholine:H+ antiporter | Animals | Unc17 of Caenorhabditis elegans |
| |
| 2.A.1.2.14 | Putative arabinose efflux porter | Bacteria | AraJ of E. coli |
| |
| 2.A.1.2.15 | Arabinose (and isopropyl β-D-thio-
galactopyranoside):H+ antiporter, YdeA | Bacteria | YdeA of E. coli |
| |
| 2.A.1.2.16 | Polyamines (spermine, spermidine, putrescene); paraquat; methylgloxal bis(guanylhydrazone):H+ antiporter (in the plasma membrane) | Yeast | TPO1 (YLL028w) of Saccharomyces cerevisiae |
| |
| 2.A.1.2.17 | Fluconazole:H+ antiporter | Yeast | Flr1 of Saccharomyces cerevisiae |
| |
| 2.A.1.2.18 | Lactose and melibiose (>>IPTG) efflux pump, SotB | Bacteria | SotB of Erwinia chrysanthemi |
| |
| 2.A.1.2.19 | The multidrug (chloramphenicol, tetra-
cycline, norfloxacin, doxorubicin, trimethoprim, acriflavin, ethidium bromide, tetraphenylphosphonium, TPP, benzalkonium, ciprofloxacin, thiamphenicol, IPTG) resistance exporter, MdfA (catalyzes both electrogenic and electroneutral transport) (Adler and Bibi, 2004) | Bacteria | MdfA of E. coli |
| |
| 2.A.1.2.20 | The fosfomycin resistance protein, YceE | Bacteria | YceE of E. coli |
| |
| 2.A.1.2.21 | The norfloxacin/enoxacin resistance protein, YceL | Bacteria | YceL of E. coli |
| |
| 2.A.1.2.22 | The chloramphenicol resistance protein,
YidY | Bacteria | YidY of E. coli |
| |
| 2.A.1.2.23 | The fructose-specific facilitator (uniporter), Ffz1 (Pina et al., 2004) | Yeast | Ffz1 of Zygosaccharomyces bailii (CAD56485) |
| |
| 2.A.1.2.24 | The probable purine efflux pump, PbuE (Nygaard and Saxild, 2005) | Bacteria | PbuE (YdhL) of Bacillus subtilis (CAB12399) |
| |
| 2.A.1.3 The Drug:H+ Antiporter-1 (14 Spanner) (DHA2) Family |
|
| 2.A.1.3.1 | (Aminotriazole, 4-nitroquinoline-N-oxide, etc.):H+ antiporter | Yeast | Atr1 of Saccharomyces cerevisiae |
| |
| 2.A.1.3.2 | (CCCP, nalidixic acid, rhodamine 6G, methylviologen, deoxycholate, SDS, organomercurials, etc.):H+ antiporter | Gram-negative bacteria | EmrB of E. coli |
| |
| 2.A.1.3.3 | (Acriflavin, ethidium bromide, fluoroquinolones, etc.):H+ antiporter | Gram-positive bacteria | LfrA of Mycobacterium smegmatis |
| |
| 2.A.1.3.4 | (Mono- and divalent organocation):H+ antiporter | Gram-positive bacteria | QacA of Staphylococcus aureus |
| |
| 2.A.1.3.5 | (Pristinamycin I and II, rifamycin, etc.):H+ antiporter | Gram-positive bacteria | Ptr of Streptomyces pristinaespiralis |
| |
| 2.A.1.3.6 | Me2+·tetracycline:2H+ or 2K+ antiporter
(the optimal Me2+ = Co2+)
(Also transports Na+ or K+out in exchange for 2H+.) | Bacteria | TetK of Staphylococcus aureus |
| |
| 2.A.1.3.7 | Actinorhodin:H+ antiporter | Gram-positive bacteria | ActVa of Streptomyces coelicolor |
| |
| 2.A.1.3.8 | Cephamycin:H+ antiporter | Gram-positive bacteria | CmcT of Nocardia lactamdurans |
| |
| 2.A.1.3.9 | Lincomycin:H+ antiporter | Gram-positive bacteria | LmrA of Streptomyces lincolnensis |
| |
| 2.A.1.3.10 | Methylenomycin:H+ antiporter | Gram-positive bacteria | MmrB of Bacillus subtilis |
| |
| 2.A.1.3.11 | Puromycin:H+ antiporter | Gram-positive bacteria | Pur8 of Streptomyces lipmanii |
| |
| 2.A.1.3.12 | Tetracenomycin:H+ antiporter | Gram-positive bacteria | TcmA of Streptomyces glaucescens |
| |
| 2.A.1.3.13 | Unconjugated bile acid uptake transporter | Bacteria | BaiG of Eubacterium sp. strain VPI 12708 |
| |
| 2.A.1.3.14 | Methylviologen (paraquat):H+ antiporter
(also exports ethidium bromide, acriflavin, malachite green, pyonine B and benzyl viologen) | Bacteria | SmvA of Salmonella typhimurium |
| |
| 2.A.1.3.15 | Rifamycin:H+ antiporter | Bacteria | RifP of Amycolatopsis mediterranei |
| |
| 2.A.1.3.16 | The Me2+·tetracycline:2H+ antiporter
(Me2+ = Co2+, Mg2+, Mn2+)(also probably
a Na+ or K+:2H+ antiporter) | Bacteria | TetA(L) of Bacillus subtilis |
| |
| 2.A.1.3.17 | The trimethoprim-sensitivity protein, YebQ (increases sensitivity to trimethoprim) | Bacteria | YebQ of E. coli |
| |
| 2.A.1.3.18 | Efflux pump for plant-bacterial signaling molecules, phytoalexins, flavenoids and salicylate as well as drugs, RmrB | Bacteria | RmrB of Rhizobium etli |
| |
| 2.A.1.3.19 | Paraquot efflux pump, PqrB (Cho et al., 2003) | Bacteria | PqrB of Streptomyces coelicolor (AAG45950) |
| |
| 2.A.1.3.20 | Long chain fatty acid efflux pump, FarB (Lee et al., 2003) | Bacteria | FarB of Neisseria gonorrhoeae (AAD54074) |
| |
| 2.A.1.4 The Organophosphate:Pi Antiporter (OPA) Family |
|
| 2.A.1.4.1 | Sugar-P:Pi antiporter (transports many sugar-phosphates - both 1- and 6-P esters) | Bacteria | UhpT of E. coli |
| |
| 2.A.1.4.2 | P-glycerate:Pi antiporter | Bacteria | PgtP of Salmonella typhimurium |
| |
| 2.A.1.4.3 | Glycerol-P:Pi antiporter | Bacteria | GlpT of E. coli |
| |
| 2.A.1.4.4 | Hexose-P:Pi antiporter regulatory protein; senses external glucose-6-P and transports it with high affinity and low efficiency | Bacteria | UhpC of E. coli |
| |
| 2.A.1.4.5 | Microsomal glucose-6-P transporter (glycogen storage disease (GSD1b); Gierke's disease protein) | Animals | GSD1b of Homo sapiens |
| |
| 2.A.1.4.6 | Glucose-6-P:Pi antiporter, Hpt (may also transport other organophosphates including C3 organophosphates). | Bacteria | Hpt of Chlamydia pneumoniae (spQ9Z7N9 & gi9979188) & pirA72050 |
| |
| 2.A.1.5 The Oligosaccharide:H+ Symporter (OHS) Family |
|
| 2.A.1.5.1 | Lactose:H+ symporter, LacY | Bacteria | LacY of E. coli |
| |
| 2.A.1.5.2 | Raffinose:H+ symporter, RafB | Bacteria | RafB of E. coli |
| |
| 2.A.1.5.3 | Sucrose:H+ symporter, CscB | Bacteria | CscB of E. coli |
| |
| 2.A.1.5.4 | Melibiose:H+ symporter, MelY (Shinnick et al., 2003) | Bacteria | MelY of Enterobacter cloacae |
| |
| 2.A.1.6 The Metabolite:H+ Symporter (MHS) Family |
|
| 2.A.1.6.1 | Citrate:H+ symporter | Bacteria | Cit of E. coli |
| |
| 2.A.1.6.2 | α-Ketoglutarate:H+ symporter | Bacteria | KgtP of E. coli |
| |
| 2.A.1.6.3 | Dicarboxylate:H+ symporter | Bacteria | PcaT of Pseudomonas putida |
| |
| 2.A.1.6.4 | (Poline/glycine-betaine):(H+/Na+) symporter (also transports taurine, ectoine, pipecolate, proline-betaine, N,N-dimethylglycine, carnitine, and 1-carboxymethyl-pyridinium) (subject to osmotic activation) | Bacteria | ProP of E. coli |
| |
| 2.A.1.6.5 | 4-Methyl-o-phthalate:H+ symporter | Bacteria | MopB of Burkholderia cepacia |
| |
| 2.A.1.6.6 | Shikimate:H+ symporter | Bacteria | ShiA of E. coli |
| |
| 2.A.1.7 The Fucose: H+ Symporter (FHS) Family |
|
| 2.A.1.7.1 | L-Fucose:H+ symporter | Bacteria | FucP of E. coli |
| |
| 2.A.1.7.2 | Glucose/galactose porter | Bacteria | Ggp of Brucella abortus |
| |
| 2.A.1.7.3 | Glucose/mannose:H+ symporter (Paulsen et
al., 1998) | Bacteria | GlcP of Bacillus subtilis |
| |
| 2.A.1.7.4 | Rat kidney Na+-dependent glucose (methyl α-glucoside) transporter, NaGLT1 (glucose:Na+:Na+=1:1) (Horiba et al., 2003) | Animals | NaGLT1 of Rattus norvegicus (BAC57446) |
| |
| 2.A.1.7.5 | 2-Deoxy-D-ribose porter, DeoP (Christensen et al., 2003) | Bacteria | DeoP of Salmonella typhimurium LT-2 (gi 16767076) |
| |
| 2.A.1.8 The Nitrate/Nitrite Porter (NNP) family |
|
| 2.A.1.8.1 | Nitrate/H+ symporter (K1)
Nitrate/nitrite antiporter (K2) | Bacteria | NarK (NarK1-K2) of E. coli |
| |
| 2.A.1.8.2 | Nitrate uptake porter | Bacteria | NasA of Bacillus subtilis |
| |
| 2.A.1.8.3 | Nitrate/nitrite uptake porter | Bacteria | NrtP of Synechococcus PCC7002 |
| |
| 2.A.1.8.4 | Nitrate transporter | Diatoms | Nitrate porter of Cylindrothelca fusiformis |
| |
| 2.A.1.8.5 | Nitrate transporter | Fungi | CrnA of Emericella nidulans |
| |
| 2.A.1.8.6 | Nitrate transporter | Algae | Nitrate porter of Chlamydomonas reinhardtii |
| |
| 2.A.1.8.7 | Nitrate/nitrite high affinity, two component uptake transporter Nrt23/Nar2 | Algae | Nrt23/Nar2 of Chlamydomonas reinhardtii; Nrt23; Nar2 (Cre) |
| |
| 2.A.1.8.8 | NO2- extrusion, NO3-/NO2- exchange permease, NarK1 | Bacteria | NarK1 of Thermus thermophilus HB8 |
| |
| 2.A.1.8.9 | NO2- extrusion, NO3-/NO2- exchange permease, NarK2 | Bacteria | NarK2 of Thermus thermophilus HB8 |
| |
| 2.A.1.8.10 | NO3-/NO2- transporter (preferential NO2- exporter) (NO3-/NO2- antiporter ?) | Bacteria | NarU of E. coli |
| |
| 2.A.1.8.11 | The 24 TMS, 2 domain, NarK1-NarK2 porter (NarK1 = a NO3-/H+ symporter; NarK2 = a NO3-/NO2- antiporter) | Bacteria | NarK of Paracoccus pantotrophus |
| |
| 2.A.1.9 The Phosphate: H+ Symporter (PHS) Family |
|
| 2.A.1.9.1 | High affinity Pi uptake porter (also functions in Mn2+ homeostasis); may transport a phosphate · Mn complex (Jensen et al., 2003) | Yeast | Ph84 of Saccharomyces cerevisiae |
| |
| 2.A.1.9.2 | Pi uptake porter | Fungi | Pho-5 of Neurospora crassa |
| |
| 2.A.1.9.3 | Pi uptake porter | Plants | PT1 of Solanum tuberosum |
| |
| 2.A.1.10 The Nucleoside: H+ Symporter (NHS) Family |
|
| 2.A.1.10.1 | Nucleoside porter (Guanosine, inosine, cytidine and thymidine but not uridine, adenosine and xanthosine are transported.) | Bacteria | NupG of E. coli |
| |
| 2.A.1.10.2 | Xanthosine porter (Xanthosine, inosine, adenosine, cytidine and thymidine but not guanosine and uridine are transported.) | Bacteria | XapB of E. coli |
| |
| 2.A.1.11 The Oxalate:Formate Antiporter (OFA) Family |
|
| 2.A.1.11.1 | The oxalate:formate antiporter | Bacteria | OxlT of Oxalobacter formigenes |
| |
| 2.A.1.12 The Sialate:H+ Symporter (SHS) Family |
|
| 2.A.1.12.1 | The sialic acid porter | Bacteria | NanT of E. coli |
| |
| 2.A.1.12.2 | The lactate/pyruvate:H+ symporter | Yeast | Jen1 (YKL217w) of Saccharomyces cerevisiae |
| |
| 2.A.1.13 The Monocarboxylate Porter (MCP) Family |
|
| 2.A.1.13.1 | The proton-linked monocarboxylate (lactate, pyruvate, mevalonate, branched chain oxo acids, β-hydroxybutyrate, butyrate, acetoacetate and acetate) uptake/efflux porter | Animals, yeast, fungi, protozoa | Mct-1 of Homo sapiens |
| |
| 2.A.1.13.2 | The low affinity aromatic amino acid (Tyr,
Trp, Phe) transporter, TAT1 (also transports N-methyl amino acids) | Animals | Tat1 of Rattus norvegicus |
| |
| 2.A.1.13.3 | The thyroid hormone transporter, MCT8 (transports L- and D-isomers of thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3'5'-triiodothyronine (rT3) and 3,3'-diiodothyronine [Km values = 2-5 μM; Leu, Phe, Trp and Tyr were not transported]) (Friesema et al., 2003) | Animals | MCT8 of Mus musculus (O70324) |
| |
| 2.A.1.14 The Anion:Cation Symporter (ACS) Family |
|
| 2.A.1.14.1 | Glucarate porter | Bacteria | GudT of Bacillus subtilis |
| |
| 2.A.1.14.2 | Hexuronate (glucuronate; galacturonate)
porter | Bacteria | ExuT of E. coli |
| |
| 2.A.1.14.3 | Putative tartrate porter | Bacteria | TtuB of Agrobacterium vitis |
| |
| 2.A.1.14.4 | Allantoate porter | Yeast | Dal5 of Saccharomyces cerevisiae |
| |
| 2.A.1.14.5 | Phthalate porter | Bacteria | Pht1 of Pseudomonas putida |
| |
| 2.A.1.14.6 | Na:Pi symporter | Animals | Npt1 of Mus musculus |
| |
| 2.A.1.14.7 | Galactonate transporter | Bacteria | DgoT (YidT) of E. coli |
| |
| 2.A.1.14.8 | Phthalate porter | Bacteria | OphD of Burkholderia cepacia |
| |
| 2.A.1.14.9 | Putative p-hydroxyphenylacetate porter | Bacteria | HpaX of Salmonella dublin |
| |
| 2.A.1.14.10 | Lysosomal sialate transporter (sialate storage disease protein) | Animals | Sialin of Homo sapiens |
| |
| 2.A.1.14.11 | Plasma membrane, high affinity nicotinate permease, Tna1 | Yeast | Tna1 of Saccharomyces cerevisiae |
| |
| 2.A.1.14.12 | Plasma membrane, high affinity biotin:H+ symporter, Vht1 | Yeast | Vht1 of Saccharomyces cerevisiae |
| |
| 2.A.1.14.13 | Broad specificity brain synaptic vesicle anion:Na+ symporter (transports glutamate, phosphate, chloride, etc.)(BNPI, EAT-4, VGLUT1) | Animals | BNPI of Rattus norvegicus |
| |
| 2.A.1.14.14 | Probable D-galactarate:H+ symporter, YhaU | Bacteria | YhaU of E. coli |
| |
| 2.A.1.14.15 | Apical membrane renal proximal tubule. Voltage-driven but Na+-independent organic anion transporter, OATv1 (transports p-aminohippurate; probably transports organic anions but not cations and not inorganic phosphate. It may catalyze excretion of various drugs, xenobiotics, and their metabolites) (Jutabha et al., 2003) | Animals | OATv1 of Sus scrofa (BAC76761) |
| |
| 2.A.1.15 The Aromatic Acid:H+ Symporter (AAHS) Family |
|
| 2.A.1.15.1 | 4-Hydroxybenzoate/protocatachuate porter | Bacteria | PcaK of Pseudomonas putida |
| |
| 2.A.1.15.2 | 3-Hydroxyphenyl propionate porter | Bacteria | MhpT of E. coli |
| |
| 2.A.1.15.3 | 2,4-Dichlorophenoxyacetate porter | Bacteria | TfdK of Ralstonia eutropha |
| |
| 2.A.1.15.4 | cis,cis-muconate porter, MucK | Bacteria | MucK of Acinetobacter sp. ADP1 |
| |
| 2.A.1.15.5 | Benzoate porter, BenK | Bacteria | BenK of Acinetobacter sp. ADPP1 |
| |
| 2.A.1.15.6 | Putative vanillate porter | Bacteria | VanK of Acinetobacter sp. ADP1 |
| |
| 2.A.1.16 The Siderophore-Iron Transporter (SIT) Family |
|
| 2.A.1.16.1 | Siderophore-iron (ferrioxamine):H+ sym-
porter, Sit1 (Arn3) (in vesicles) | Yeast | Sit1 (YEL065w) of Saccharomyces cerevisiae |
| |
| 2.A.1.16.2 | The ferric enterobactin:H+ symporter, Enb1 | Yeast | Enb1 (YOL158c) of Saccharomyces cerevisiae |
| |
| 2.A.1.16.3 | The ferric triacetylfusarinine C:H+ symporter, Taf1 | Yeast | Taf1 (YHL047c) of Saccharomyces cerevisiae |
| |
| 2.A.1.16.4 | The ferrichrome:H+ symporter, Arn1p (Moore et al., 2003) | Yeast | Arn1 of Saccharomyces cerevisiae (NP_011823) |
| |
| 2.A.1.17 The Cyanate Porter (CP) Family |
|
| 2.A.1.17.1 | Cyanate transport system | Bacteria | CynX of E. coli |
| |
| 2.A.1.18 The Polyol Porter (PP) Family |
|
| 2.A.1.18.1 | D-Arabinitol:H+ symporter | Bacteria | DalT of Klebsiella pneumoniae |
| |
| 2.A.1.18.2 | Ribitol:H+ symporter | Bacteria | RbtT of Klebsiella pneumoniae |
| |
| 2.A.1.19 The Organic Cation Transporter (OCT) Family |
|
| 2.A.1.19.1 | The basolateral multivalent, potential-
sensitive, organic cation (tetramethyl-
ammonium; N'-methylnicotinamide; cationic drugs, xenobiotics, vitamins, neuro-
transmitters, etc.) transporter (uni-
porter)-1, Oct1 | Animals | Oct1 of Rattus norvegicus |
| |
| 2.A.1.19.2 | The polyspecific organic cation (tetraethyl ammonium, guanidinium):putative H+ antiporter, OctN1 | Animals | OctN1 of Homo sapiens |
| |
| 2.A.1.19.3 | The polyspecific organic cation (L- and D-carnitine, acetyl carnitine, γ-butyro-
betaine, glycinebetaine, β-lactam anti-
biotics with a quaternary nitrogen such as cephaloridine, and others):Na+ symporter, OctN2 (may also function as a uniporter for some organic cations)
| Animals | OctN2 of Homo sapiens |
| |
| 2.A.1.19.4 | The polyspecific organic anion, cation and neutral molecule transporter, Oat1 (Slc22a6) (transports neutral compounds such as cardiac glycosides [i.e., ouabain] and steroids [i.e., aldosterone; cortisol; dexamethasone]; cationic compounds such as N-propylajmalinium, and anionic compounds such as p-aminohippurate, dicarboxylates, cyclic nucleotides, prostaglandins, urate, β-lactam antibiotics, nonsteroidal anti-inflammatory drugs, diuretics, bile salts and steroid conjugates [i.e., estrone-3-sulfate and estradiol-17-
glucuronide]) transporter (H+ symporter or uniporter) Probably catalyzes organic anion (uptake):dicarboxylate (efflux) antiport in the basolateral membrane of kidney proximal tubules) (Eraly et al., 2003a,b)
| Animals | Oat1 of Rattus norvegicus |
| |
| 2.A.1.19.5 | The putative apical polyspecific organic
cation transporter (cation:H+ or cation:cation antiporter), Oct2 (substrates include monoamine neurotransmitters such as dopamine, noradrenaline, adrenaline and 5-hydroxytryptamine)
| Animals | Oct2 of Sus scrofa |
| |
| 2.A.1.19.6 | The polyspecific potential-sensitive organic cation uptake transporter, Oct3 (transport substrates include the neurotoxin 1-methyl-
4-phenylpyridinium and monoamine neuro-
transmitters such as dopamine)
| Animals | Oct3 of Rattus norvegicus |
| |
| 2.A.1.19.7 | The polyspecific organic anion (and cation) (anions: p-aminohippurate, ochratoxin A, estrone sulfate, anionic drugs, anionic neurotransmitter metabolites; cation: cimetidine) transporter, Oat3 (slc22a8) (catalyzes organic anion (uptake):dicar-
boxylate (efflux) in the basolateral membrane of the renal proximal tubule) (Eraly et al., 2003a,b)
| Animals | Oat3 of Rattus norvegicus |
| |
| 2.A.1.19.8 | The mouse organic cation transporter, mBOCT (transports various cations and anions including cyclic GMP)
| Animals | mBOCT of Mus musculus |
| |
| 2.A.1.19.9 | The osteosclerosis protein, Roct (organic anion transporter 3, Oat3) (Slc22a8) (catalyzes organic anion (uptake):di-
carboxylate (efflux) in the basolateral membrane of the renal proximal tubule) (Eraly et al., 2003a,b)
| Animals | Roct (Oat3) of Mus musculus |
| |
| 2.A.1.19.10 | The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (Km = 1 µM), dehydroepiandrosterone sulfate (Km = 60
µM), many anionic drugs, diuretics, bile salts, and ochratoxin A) (catalyzes Na+-independent efflux). | Animals | Oat4 of Homo sapiens |
| |
| 2.A.1.19.11 | The apical proximal tubular renal urate:anion exchanger, URAT1 (Slc22a12) (catalyzes Na+-independent anion efflux (secretion)) (Eraly et al., 2003a,b) | Animals | URAT1 of Homo sapiens |
| |
| 2.A.1.20 The Sugar Efflux Transporter (SET) Family |
|
| 2.A.1.20.1 | Efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, α-methylglucoside, and isopropyl β-thiogalactosides (IPTG); amino-
glycosides, streptomycin and kanamycin, weakly expelled
| Bacteria | SetA (YabM) of E. coli |
| |
| 2.A.1.20.2 | Efflux system for lactose and glucose, but not IPTG or galactose
| Bacteria | SetB (YeiO) of E. coli |
| |
| 2.A.1.20.3 | Putative efflux system for unknown substrates (none of those exported by SetA and SetB are exported by SetC)
| Bacteria | SetC (YicK) of E. coli |
| |
| 2.A.1.20.4 | Efflux system for arabinose and IPTG (>>lactose), SotA
| Bacteria | SotA of Erwinia chrysanthemi |
| |
| 2.A.1.21 The Drug:H+ Antiporter-3 (12 Spanner) (DHA3) Family |
|
| 2.A.1.21.1 | The macrolide (erythromycin; oleando-
mycin; azithromycin) efflux, MefA
| Bacteria | MefA of Streptococcus pyogenes |
| |
| 2.A.1.21.2 | The multidrug (erythromycin, tetracycline, puromycin, bleomycin) resistance protein,
Cmr
| Bacteria | Cmr of Corynebacterium glutamicum |
| |
| 2.A.1.21.3 | The tetracycline resistance determinant, TetV
| Bacteria | TetV of Mycobacterium smegmatis |
| |
| 2.A.1.21.4 | Multidrug resistance efflux pump, Tap
| Bacteria | Tap of Mycobacterium fortuitum |
| |
| 2.A.1.22 The Vesicular Neurotransmitter Transporter (VNT) Family (Related to the SP Family (TC #2.1.1)) |
|
| 2.A.1.22.1 | Synaptic vesicle neurotransmitter (e.g., dopamine) transporter
| Animals | SV2 of Rattus norvegicus |
| |
| 2.A.1.23 The Conjugated Bile Salt Transporter (BST) Family |
|
| 2.A.1.23.1 | Conjugated bile salt:H+ symporter, CbsT1
| Bacteria | CbsT1 of Lactobacillus johnsonii 100-100 |
| |
| 2.A.1.23.2 | Taurocholate:cholate antiporter, CbsT2 | Bacteria | CbsT2 of Lactobacillus johnsonii 100-100 (AAC34380) |
| |
| 2.A.1.24 The Unknown Major Facilitator-1 (UMF1) Family |
|
| 2.A.1.24.1 | 58.8 KDa protein, YCL038c
| Yeast | YCL038c of Saccharomyces cerevisiae |
| |
| 2.A.1.25 The Peptide-Acetyl-Coenzyme A Transporter (PAT) Family |
|
| 2.A.1.25.1 | (Putative) Acetyl-CoA:CoA antiporter
| Animals | Acetyl CoA transporter of Homo sapiens |
| |
| 2.A.1.25.2 | Cell wall degradation product (peptides and glycopeptides including N-acetylglucos-
aminyl β-1,4-anhydro-N-acetyl-muramyl-
tripeptide) as well as penicillin derivative uptake porter, AmpG
| Bacteria | AmpG of E. coli |
| |
| 2.A.1.26 The Unknown Major Facilitator-2 (UMF2) Family |
|
| 2.A.1.26.1 | 41.4 KDa Protein, YcaD
| Bacteria | YcaD of E. coli |
| |
| 2.A.1.27 The Phenyl Propionate Permease (PPP) Family |
|
| 2.A.1.27.1 | The phenylpropionate porter, HcaT
| Bacteria | HcaT (YfhS) of E. coli |
| |
| 2.A.1.28 The Feline Leukemia Virus Subgroup C Receptor (FLVCR) Family |
|
| 2.A.1.28.1 | Cell surface receptor (c-receptor) for anemia-inducing feline leukemia virus
subgroup C
| Animals | C-receptor of Homo sapiens |
| |
| 2.A.1.29 The Unknown Major Facilitator-4 (UMF4) Family |
|
| 2.A.1.29.1 | Archaeal open reading frame
| Archaea | Orf of Archaeoglobus fulgidus |
| |
| 2.A.1.29.2 | Archaeal open reading frame
| Archaea | Orf of Aeropyrum pernix |
| |
| 2.A.1.30 The Putative Abietane Diterpenoid Transporter (ADT) Family |
|
| 2.A.1.30.1 | Putative abietane uptake permease (in gene cluster for degradation of abietane diterpenoids), DitE
| Bacteria | DitE of Pseudomonas abietaniphila BKME-9 |
| |
| 2.A.1.31 The Nickel Resistance (Nre) Family |
|
| 2.A.1.31.1 | The Ni2+ efflux pump, NreB (Ni2+ inductible)
| Bacteria | NreB of Achromobacter xylosoxidans plasmid pTOM |
| |
| 2.A.1.31.2 | The Ni2+ resistance protein, NrsD
| Bacteria | NrsD of Synechocystis PCC6803 |
| |
| 2.A.1.32 The Putative Aromatic Compound/Drug Exporter (ACDE) Family |
|
| 2.A.1.32.1 | Putative aromatic compound/drug exporter
| Bacilli | YitG of Bacillus subtilis |
| |
| 2.A.1.33 The Putative YqgE Transporter (YqgE) Family |
|
| 2.A.1.33.1 | MFS homologue, YqgE
| Bacteria; Archaea | YqgE of Bacillus subtilis |
| |
| 2.A.1.35 The Fosmidomycin Resistance (Fsr) Family |
|
| 2.A.1.35.1 | The fosmidomycin resistance (Fsr) protein (confers fosmidomycin, trimethoprim and carbonylcyanide m-chlorophenylhydrazone (CCCP) resistance) | Bacteria | Fsr of E. coli |
| |
| 2.A.1.35.2 | The cationic microbial peptide resistance (RosA) protein | Bacteria | RosA of Yersinia enterocolitica |
| |
| 2.A.1.36 The Acriflavin-sensitivity (YnfM) Family |
|
| 2.A.1.36.1 | The acriflavin-sensitivity protein, YnfM (increases sensitivity to acriflavin specifically) | Bacteria | YnfM of E. coli |
| |
| 2.A.1.37 The Putative Short Chain Fatty Acid Porter (AtoE) Family |
|
| 2.A.1.37.1 | The putative short chain fatty acid uptake transporter (closest to family 2.A.1.3) | Bacteria and archaea | AtoE (YegB) of E. coli |
| |
| 2.A.1.38 The Enterobactin (Siderophore) Exporter (EntS) Family |
|
| 2.A.1.38.1 | The enterobactin (siderophore) exporter, EntS | Bacteria | EntS (YbdA) of E. coli |
| |
| 2.A.1.39 The Vibrioferrin (Siderophore) Exporter (PrsC) Family |
|
| 2.A.1.39.1 | The vibrioferrin (siderophore) exporter, PrsC (Tanabe et al., 2003) | Bacteria | PrsC of Vibrio parahaemolyticus (BAC16546) |
| |
| 2.A.1.40 The Purine Transporter, AzgA (AzgA) Family |
|
| 2.A.1.40.1 | The purine (hypoxanthine/adenine/guanine) transporter, AzgA (Cecchetto et al., 2004) | Fungi | AzgA of Aspergillus (Emericella) nidulans (CAE00849) |
| |
| 2.A.1.41 The Putative Bacteriochlorophyll Delivery (BCD) Family |
|
| 2.A.1.41.1 | Putative pigment transporter (Young and Beatty, 1998) | Photosynthetic bacteria | LhaA of Rhodobacter capsulatus |
| |
| 2.A.1.41.2 | Putative pigment transporter (Young and Beatty, 1998) | Photosynthetic bacteria | PucC of Rhodobacter capsulatus |
| |
| 2.A.1.41.3 | Putative bacteriochlorophyll synthase | Photosynthetic bacteria | Bch2 of Rhodobacter capsulatus |
| |
| 2.A.1.42 The Lysophospholipid Transporter (LplT) Family |
|
| 2.A.1.42.1 | The lysophospholipid transporter, LplT (Harvat et al., 2005) | Bacteria | LplT of E. coli (NP_417312) |
| |
| 2.A.1.42.2 | The putative lysophospholipid transporter-2-acyl glycerophosphoethanolamine acyl transferase/acyl ACP synthetase (LplT-Pls-ACS) fusion protein. | Bacteria | The fused LplT-Pls-ACS of Bradyrhizobium japonicum (BAC47589) |
| |
| 2.A.1.43 The Putative Magnetosome Permease (PMP) Family |
|
| 2.A.1.43.1 | The putative magnetosomal permease, MamH (Schubbe et al., 2003) | Bacteria | MamH of Magnetospirillum gryphiswaldense (CAE12030) |
| |
| 2.A.1.43.2 | The putative magnetosome (Fe?) permease fused to a C-terminal YedZ-like domain (T. von Rozycki and M.H. Saier, Jr., unpublished results) | Bacteria | PMP of Magnetospirillum magnetotacticum (gi_23014927) |
| |
| 2.A.1.44 The L-Amino Acid Transporter-3 (LAT3) Family |
|
| 2.A.1.44.1 | The L-amino acid transporter-3, LAT3 (transports neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine by a Na+-independent, electroneutral, facilitated diffusion process; also transports amino acid alcohols) (Prostate cancer up-regulated gene product) | Animals | LAT3 (POV1) of Homo sapiens (BAD00152) |
| |
| 2.A.1.45 The 2,4-diacetylphloroglucinol (PHL) Exporter (PHL-E) Family |
|
| 2.A.1.45.1 | The 2,4-diacetylphloroglucinol resistance/general stress porter, PhlE (Abbas et al., 2004) | Bacteria | PhlE of Pseudomonas fluorescens (CAD65845) |
| |
| 2.A.1.46 The Unknown Major Facilitator-5 (UMF5) Family |
|
| 2.A.1.46.1 | Probable transporter | Bacteria | Probable transporter of Bordetella pertussis (NP_878946) |
| |
| 2.A.1.46.2 | Putative transporter | Bacteria | Putative transporter of Tropheryma whipplei (AAO44294) |
| |
| 2.A.1.47 The Unknown Major Facilitator-6 (UMF6) Family |
|
| 2.A.1.47.1 | Putative transporter | Bacteria | Putative transporter of Lactobacillus plantarum (NP_784357) |
| |